They have never been the best of friends.
But 50 Cent hit rival Kanye West below the belt by branding his girlfriend Kim Kardashian 'trash'.
The Get Rich or Die Tryin' star has surely kicked off a new feud with his old sparring partner with his latest comments.
He told XXL Magazine: 'You know how it is? One man’s trash is another man’s treasure.'
The 37-year-old New Yorker made the quip as he shared his thoughts on the The College Dropout's touching ode to his lover, the charmingly titled Perfect B****.
He said: 'I mean, if that man feel like she's perfect, then she’s perfect.
'He could mean it and you’ll end up singing the words to it because he’s Kanye.'
But he also issued a note of caution, pointing out his doubts that there is such a thing as the perfect woman.